http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3567040-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2014-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edd592735d96fbe2eb349aa79efc02df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a54898fc610bd65cdb59500595e265c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_187ced7bd3ea5d6d26f71c06a953765c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e8f11d91d07bb7f188e40c9aa68e491 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_643835829612cb5b64edaf3816117112 |
| publicationDate | 2019-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3567040-A1 |
| titleOfInvention | Method for the preparation of intermediates useful for the synthesis of [1,2,4]-triazolo[4,3-a]pyridines |
| abstract | The present application discloses a method comprising: (A)(i) admixing a methylnicotinate of Formula (I):wherein R3 is Cl, Br, or I, and R4 is alkyl;with 1,3,5-triazine, and a base, under conditions sufficient to form a naphthyridinone of Formula (II):(ii) admixing the naphthyridinone of Formula (II) with methoxyethanol, a base, and a copper (I) catalyst, under conditions sufficient to form 3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one ("NAPH"):or (B):(i) admixing protected 2-alkoxypyridin-4-ylamine with a lithium reagent, under conditions sufficient to form the protected N-(3-formyl-4-amino-2-alkoxy)pyridine:wherein PG is a protecting groupwherein R<sup>8</sup>is an alkyl group;(ii) admixing the protected N-(3-formyl-4-amino-2-alkoxy)pyridine with 1-hydroxy-2-(2-methoxyethoxy)ethane-1 -sulfonate:and base, under conditions sufficient to form a naphthyridine of Formula (III):; and(iii) acidifying the naphthyridine of Formula (III), under conditions sufficient to form 3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one ("NAPH"): |
| priorityDate | 2013-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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