| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c0e8d16adfed30a2231ba4b252c19aa |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate |
2017-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89c2ff078c1e14cedf149a8f1efd4753
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01c1863c34a8b9778ef392fcc3237e1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f8b4ead269f72001f8066d7bd58d711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_565dd0c7e65cb0821c7fb6a1633b9414
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5752e42ea7b8c1a05d3e63a1b9a7b2cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbb7134889db7512060a512136a3e9ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5d281cf0b3890cc6d5937b88ce96bd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88d28efefca8e2833c0b641acceb7564 |
| publicationDate |
2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3556769-A1 |
| titleOfInvention |
Polymyxin derivative, preparation method and application thereof |
| abstract |
Provided are a polymyxin derivative having a general formula I structure, and a preparation method and an application thereof. The method for preparing the polymyxin derivative comprises the following steps: (1) an Fmoc-AA-OP side chain free amino group of a protected basic amino acid reacting with a halogenated resin to obtain an Fmoc-AA-OP-resin; (2) the Fmoc-AA-OP-resin being coupled one by one to obtain a linear peptide-resin; (3) the linear peptide-resin selectively removing a protective group, and carrying out solid-phase cyclization to obtain a cyclic peptide-resin; (4) the cyclic peptide-resin undergoing acidic hydrolysis and ether precipitation to obtain a crude product of a cyclic polypeptide; (5) the crude product being purified and/or salt transferred and lyophilized to obtain a pure product of the cyclic polypeptide. The polymyxin derivative may be used for preparing an antibacterial drug, and used in particular for preparing an antibacterial drug having an expanded antibacterial spectrum, improved antibacterial activity and reduced renal toxicity, comprising preparing an antibacterial drug against a "superbugs" which carries the NDM-1 gene. |
| priorityDate |
2016-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |