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filingDate 2017-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb2303b73f12114f026e0e61c7d052a0
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publicationDate 2019-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3551666-A1
titleOfInvention Antibody variants transmigrating the blood-brain barrier and uses thereof
abstract The present invention relates, in general, to polypeptides capable of transmigrating the blood-brain barrier, and uses thereof. More specifically, the present invention relates to polypeptides derived by site-directed mutagenesis of an existing antibody fragment and uses thereof, and methods of making such molecules. The polypeptides of the present invention show enhanced blood-brain barrier crossing and brain exposure levels in vitro and in vivo.
priorityDate 2016-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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