http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3548516-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4caa77d6ee705e63ba9d4a406c6e5094 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-624 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-283 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07f1ddd4cf02d0dd7dda1a82b5b9a833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d164893c8be534c2770e5b6e869dd2c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fdb4d35409e35a21f31ee5cea41a7b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2dd56dbe9aedbc4bc5dbd566d31d9f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5f4ad5630c9cc255a3794154c4785bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45c8d7595ad9626041865b3d39da8adf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e7f81fd8ef4ed0da0d54e0743b86ea9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_738e2750d49439efd088ae5aef4ff836 |
| publicationDate | 2019-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3548516-A1 |
| titleOfInvention | A cd33-, cd16- and cd123-specific single chain triplebody |
| abstract | The present invention relates to a nucleic acid molecule encoding a single chain triplebody capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic acid molecule comprises: (a) a nucleic acid molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic acid molecule of (b), wherein each thymine is replaced by uracil; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic acid molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain triplebody capable of specifically binding to CD33, CD16 and CD123. Furthermore, the present invention also relates to a single chain triplebody capable of specifically binding to CD33, CD16 and CD123 encoded by the nucleic acid molecule of the invention, as well as to a composition comprising the nucleic acid molecule, the vector, the host cell and/or the single chain triplebody of the invention. Also encompassed by the present invention are the nucleic acid molecule, the vector, the single chain triplebody and/or the composition of the invention for use in the treatment of acute myeloid leukaemia and/or myelodysplastic syndrome, as well as a method of treating acute myeloid leukaemia and/or myelodysplastic syndrome. |
| priorityDate | 2016-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 308.