http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3543237-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14687eb1d34a9a00bd12725a2e42d611 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 |
| filingDate | 2018-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c69b2f56b0e5e3143c5c0243c02c762d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39903f7e64f07e6483356eb190f7e4a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c27279140df140e91fc364408a2d35f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_128edcfb81fe388985361c06461b60b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12d1810ab414288ce82be96cca89cbbc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8937c75ae2af5e0d009810ed8bb7c04e |
| publicationDate | 2019-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3543237-A1 |
| titleOfInvention | Simple preparation method for avibactam intermediate |
| abstract | The present invention discloses a simple process for preparing an intermediate for avibactam. In the invention, a compound of Formula III as the raw material is hydrolyzed in an alkaline condition, then acidized to prepare a compound of Formula IV, and the resulting compound of formula IV and a solid phosgene or diphosgene are concurrently subjected to the urea cyclization and the chloroformylation reaction in the presence of an organic base and a catalyst to obtain a compound of formula V, and then the compound of formula V is amidated to obtain the final product (II). In the present invention, a "one-pot" method is adopted for urea cyclization, chloroformylation, and amidation reaction, and the intermediate products do not need post-treatments such as separation and purification. The present invention uses an inexpensive and easily accessible raw material; the process is simple; the operability is strong; no specific protection agent or carbonylation reagent is required; the reaction has a high atom economy and a low cost. Besides, the production process is green and environment-friendly; the resulting product (II) has a high purity and yield, which facilitates cost reduction and green production of avibactam (I). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190082194-A |
| priorityDate | 2017-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.