http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3526603-A1

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-487
filingDate 2017-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e355c7ff71aaef402647a86bdc370d4
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publicationDate 2019-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3526603-A1
titleOfInvention Nanopore voltage methods
abstract A method for sequencing a nucleic acid molecule includes providing a sequencing cell (200) having a nanopore (216) in a membrane (214) that resides over a well (205), a first electrode (202) at a bottom of the well, a second electrode (210) in a chamber (215) above the membrane, and an electrolyte (206, 208) in the well (205) and the chamber (215). The first electrode (202) is configured to facilitate non-Faradaic conduction of ionic current and forms a capacitance with ions in the electrolyte. A first voltage signal (1310) is applied across the first and second electrodes (202, 210), thereby creating a force that moves a nucleic acid molecule in the sequence cell through the nanopore (216). The first voltage signal (1310) increases to compensate for changes in the capacitance at the first electrode (202) during application of the first voltage signal. The method further includes determining signal values measured during the first voltage signal, which correspond to one or more nucleotides in the nucleic acid molecule.
priorityDate 2016-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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