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publicationDate 2019-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3515520-A1
titleOfInvention Devices and methods for vascular hyperperfusion of extravascular space
abstract A method of delivering a therapeutic substance for treatment to a region of the body through vascular isolation and manipulation of fluid flux into and from the region of the body including the steps of: restricting vascular inflow to the region of the body; washing out oncotically active plasma proteins from the region of the body by increasing the outward oncotic pressure gradient from the region of the body; inducing ischemia in the region of the body; controlling the pressure and fluid flow of the main blood vessels to and from the region of the body; providing the therapeutic substance to the region of the body when the fluid flow to the region of the body is controlled.
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