| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a3c763d912c1f039d8e731cceca821f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-126
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1812
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 |
| filingDate |
2017-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9aebd92d5c954c350e123491382dd030
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fffb93efca5e1edad924995e835a5868
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f582f4ce500cd49b45a8d5caee302ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edd3c2fab05d73d312348208b660be8b |
| publicationDate |
2019-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3512570-A2 |
| titleOfInvention |
Novel liposomal gadolinium (gd) contrast agent "nmrx" for t1-mri |
| abstract |
The present invention is directed towards new chemical entities based on a lipid-paramagnetic metal ion chelate. The lipid portion of the compound intercalates into the membrane of a liposome. The compounds of the invention find particular use as paramagnetic contrast media for magnetic resonance imaging. It has been surprisingly discovered that the liposomal contrast media do not substantially cross the placental barrier into the vasculature of the fetus(es) when administered to a pregnant subject. These novel compounds are useful in the diagnosis of disorders and diseases in both gravid and non- gravid subjects. The invention is also directed towards pharmaceutical compositions comprising these compounds and the uses of these compounds. |
| priorityDate |
2016-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |