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filingDate 2017-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6026b68b3afc096d34d5e79c1ab9813
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publicationDate 2019-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3510166-A1
titleOfInvention In vitro method for identification and analysis of proteins with stem cell function using a three-dimensional cell culture model of the sweat gland
abstract The present invention relates to an in vitro method for identification and analysis of proteins with stem cell function in which initially at least a three-dimensional sweat gland equivalent with 500 to 500,000 sweat gland cells and a diameter of 100 to 6000 µm is provided and subsequently proteins with stem cell function are identified and analyzed in this equivalent. It is preferable when in a further method step c) the influence of test substances on the proteins previously identified in step b) is investigated. Since the three-dimensional sweat gland equivalents used in step a) have differently differentiated cells and depict the in vivo situation well, the measured data obtained with the in vitro method according to the invention may be readily transferred to the in vivo situation.
priorityDate 2016-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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