| abstract |
Generally, the present invention relates to the field of antibodies. In particular, it relates to multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. The invention further relates to nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies. The invention also relates to methods of isolating the antibodies. |