http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3502694-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_35dbc60da9891d57c4047fb7b8689516 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-005 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C11D3-3845 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52 |
| filingDate | 2018-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a0c92a663713ffe60d951584d8e4d89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e235a5f74972cba71260e36bd17ce7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fb17b9f849d1d1f97c13921643c9f33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6aa795988a89206d56aea3d8d13cebb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_430b447547eb94af3c22a3d12db9daab |
| publicationDate | 2019-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3502694-A1 |
| titleOfInvention | Method for bio-sensing a binding ability among a biomolecule and a virus using viral-lasing detection probes |
| abstract | The selective amplification of DNA in PCR is used to exponentially increase the signal in molecular diagnostics for nucleic acids, but there are no analogous techniques for signal enhancement in clinical tests for proteins or cells. Instead, the signal from affinity-based measurements of these biomolecules depends linearly on the probe concentration. Substituting antibody-based probes tagged for fluorescent quantification with lasing detection probes would enable a new platform for biomarker quantification based on optical amplification. Here, we construct a viral laser which bridges synthetic biology and laser physics, and demonstrate viral-lasing probes for bio-sensing. At the transition to lasing, the photon flux from the probes increases by five orders of magnitude and narrows the spectral linewidth to below 5.0 nm. Viral-lasing probes display an unprecedented > 500,000 % increase in signal from only a 50 % increase in probe concentration, using fluorimeter-compatible optics, and can detect biomolecules at clinically-relevant concentrations. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021207699-A1 |
| priorityDate | 2017-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 148.