| abstract |
The invention provides a hydrogel comprising an aqueous chitosan solution and a water-soluble linker agent. The linker agent is a block copolymer composing non-degradable block such as poly(ethylene glycol) and hydrolytic degradable block such as poly(amino acid) and polyester. Both ends of the block copolymer are terminated with active group such as glyoxylic acid, uronic acid and aldehyde benzoic acid. When the two main components are mixed together, the resulting solution will undergo spontaneous gelation at mild condition. The resulting hydrogel is able to retain the stability of biopharmaceuticals fully, therefore, which is qualified to serve as drug vehicles usedand topical applications. |