| abstract |
The present application relates to new, directed against the target C4.4a binder-active ingredient conjugates (ADCs) of N, N-dialkylauristatines, active metabolites of these ADCs, processes for the production of these ADCs, the use of these ADCs for the treatment and / or prevention of Diseases and the use of these ADCs for the production of medicaments for the treatment and / or prevention of diseases, in particular of hyperproliferative and / or angiogenic diseases such as, for example, cancer. Such treatments can be carried out as monotherapy or in combination with other drugs or other therapeutic measures. |