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filingDate 2017-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_477edc785098eb29d407bd0ba0fdb913
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publicationDate 2019-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3495487-A1
titleOfInvention Promoter with a region rich in cytosine-guanine dinucleotides, vectors, cellular lines, method for producing recombinant protein
abstract The present invention relates to the field of genetic engineering, preferably the expression of recombinant proteins (RP). In particular, the invention relates to a promoter and variants thereof having an equal function and more than 90% sequence identity. The promoter comprises a fragment of 1147 base pairs (bp) of a first promoter, promoter of the β-actin gene of thegenome, enriched in cytosine-guanine dinucleotides (RegCG). The first promoter can be upstream of a second promoter, cytomegalovirus (CMV) promoter. The invention also relates to vectors, transfected cellular lines and a method for producing RP in mammal cells that have been transfected with vectors containing said promoter or variants thereof.
priorityDate 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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