http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3494980-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ad9845d98d5e7907ed08a8d192aca2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb0eccfa05db1802da3590d530c62b61 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-646 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-646 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_add51f6d3f071e48f404b20f8fb9f903 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7096014e7ce4088c179a707d4952d9a1 |
| publicationDate | 2019-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3494980-A1 |
| titleOfInvention | Spider web extract, method of preparation, and use for treating prostate cancer |
| abstract | The invention is related to a method for obtaining spider web extract by grinding the spider web collected from nature by using liquid nitrogen and balls, precipitating the spider web powder in a solvent containing ethyl acetate, hydrochloric acid and dimethyl sulphoxide and thus obtaining a mixture containing a liquid extract fraction and a solid fraction; and then optionally mixing the solid or the semi-solid extract with a polar rearrangement solvent containing dimethyl sulphoxide, water, n-butanol, isopropanol, n-propanol, ethanol and methanol or a mixture thereof and said obtained spider web extract has the selective and targeted anti-cancer effect by increasing the production of reactive oxygen species and creating DNA damage and protein damage (Figure 4) in prostate cancer cells (Figures 2 and 3) without creating a lethal effect on healthy cells (Figure 1), then leading to a programmed cell death through intrinsic and extrinsic apoptosis pathways (Figures 8 and 9) by activating cell control pathways (Figure 7). |
| priorityDate | 2017-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 371.