http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3468620-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78941ed5a01bfbcd48376e1fdb485b19 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3839 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0489 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-004 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2017-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9531201c66ace4f80006630bac9d5f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d82389b56e7e938cfa5fbee82f181bac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8bb5c0fd5438e9def96710fd5d633d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17f57e343045dd7447fb2d49814829d4 |
| publicationDate | 2019-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3468620-A2 |
| titleOfInvention | 18 f-labeled bisphosphonates for pet imaging |
| abstract | A novel method for rapidly and efficiently introducing fluorine into the P-C-P backbone of bisphosphonates starting from readily accessible diazomethylenebisphosphonate esters is provided. The method is applied successfully to create novel [ 18 F]-labeled bisphosphonates for positron emission tomography imaging. Some versions of the method include reacting a diazomethylenebisphosphonate tetraalkyl ester with a fluorinating agent in the presence of an acidic HF/base complex and a t -butyl hypohalite to produce a halofluoromethylenebisphosphonate tetraalkyl ester, and dealkylating the halofluoromethylenebisphosphonate alkyl ester to produce a halofluoromethylenebis(phosphonic acid). Methods of replacing the halogen group with hydrogen are further provided. 18 F-labeled bisphosphonates prepared by the methods, and methods of using such compounds for positron emission tomography imaging in patients and animal models, are also provided. |
| priorityDate | 2016-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.