| abstract |
The invention provides antibodies that specifically bind human Į-synuclein with a high affinity and reduces Į-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating Į-synuclein antibodies, and methods of using Į-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies. |