abstract |
The purpose of the present invention is to provide novel miR-143 derivatives described herein that can be used as oligonucleotide therapeutics. nA microRNA-143 derivative wherein nthe first strand is an oligonucleotide consisting of na sequence of SEQ ID NO: 3; or na sequence in which one or two bases are substituted, deleted, inserted or added to the sequence of SEQ ID NO: 3 and ndoes not include a 3'-end modification, but may include a 5'-end modification; and nthe second strand is an oligonucleotide consisting of na sequence of SEQ ID NO: 4 or na sequence in which one or two bases are substituted, deleted or inserted to the sequence of SEQ ID NO: 4 and nincludes a 3'-end modification, and may include a 5'-end modification; nor na sequence of SEQ ID NO: 5 or na sequence in which one or two bases are substituted or inserted to the sequence of SEQ ID NO: 5 and ndoes not include a 3'-end modification, and may include a 5'-end modification; nwherein nthe 3'-end modification is a 1 to 5-mer oligonucleotide derivative which may include a nucleoside derivative(s) and/or modified internucleoside linkage(s) or a benzene-pyridine derivative and nthe 5'-end modification is a phosphate ester moiety or a group of the formula: =CQ 1 - P(=O)(OH) 2 , wherein Q 1 is hydrogen, halogen, substituted or unsubstituted alkyl, nsubstituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or nsubstituted or unsubstituted alkyloxy. |