http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3443956-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f4d86235703b3e2a1cb10b98722d80d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 |
| filingDate | 2017-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3443956-A1 |
| titleOfInvention | A compound increasing endocannabinoids concentration in a subject for use for preventing and/or treating a social behavior disorder |
| abstract | The present invention concerns a compound increasing endocannabinoids (eCBs) concentration, a CB1 R agonist or a TRPV1 agonist for use for preventing and/or treating a social behaviors disorder, such as autism, excessive shyness, sociopathy, anxiety, mood disorder or depression. Indeed, inventors show a sex specific modulation of social interaction and medial prefrontal cortex endocannabinoid/mGlu5-dependent LTD (a critical actor of plasticity and reliable prefrontal endophenotypes of neuropsychiatric diseases) in adult rats. TRPV1 blocking leads to reduced social interaction and blocked endocannabinoid/mGlu5-dependent LTD in medial prefrontal cortex(mPFC) of female rats whereas CB1 R blocking leads to blocked endocannabinoid/mGlu5-dependent LTD in mPFC of adult male. In utero exposure to cannabinoids modified social behaviors as well as mPFC endocannabinoid/mGlu5-dependent LTD at adulthood of male rats but not female rats. Increasing endocannabinoids concentration could compensate the effects of in utero exposure in males through activation of CB1 R. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3943077-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115282134-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022018115-A1 |
| priorityDate | 2017-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.