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filingDate 2016-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3434762-A1
titleOfInvention Modified natural killer cells and natural killer cell lines having increased cytotoxicity
abstract NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.
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