http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3433619-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5073a0063d6be9e25c14d2af0a1ee89 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4718 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5432 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 |
| filingDate | 2017-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_077369dbfe9de65b9d1f4d2cd11e01ad |
| publicationDate | 2019-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3433619-A1 |
| titleOfInvention | Free functional annexin levels in plasma as a biomarker of cardiovascular risk |
| abstract | The present invention relates to a method for diagnosing the occurrence of a vascular dysfunction or a vascular injury in a subject, said method comprising a step consisting of determining in a plasma sample obtained from said subject the level of free annexin. The present invention further relates to a method for determining whether a subject is at risk for severe vasculopathy, cardiovascular complications and cardiovascular disease, said method comprising a step consisting of determining in a plasma sample obtained from said subject the level of free annexin. Preferably, the methods further comprise the steps consisting of determining the level of circulating phosphatidylserine positive (PS+) microparticles (MPs) in the plasma sample obtained from said subject and calculating the ratio free annexin / circulating PS+ MPs. The invention also relates to a kit for use in a method according to the invention and to a phosphatidylserine antagonist, for use in a method of treatment of severe vasculopathy, cardiovascular complications and cardiovascular disease in a subject having a decreased level of free annexin as compared to a free annexin reference level, wherein the method comprises a determination of the free annexin level in a plasma sample of said subject. Preferably, a phosphatidylserine antagonist is for use in a method of treatment of severe vasculopathy, cardiovascular complications and cardiovascular disease in a subject having a decreased ratio of free annexin / circulating PS+ MPs as compared to a free annexin / circulating PS+ MPs reference ratio, wherein the method further comprises the steps consisting of determining the circulating PS+ MPs level in said plasma sample and calculating the free annexin / circulating P8+ MPs ratio. |
| priorityDate | 2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 177.