| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90e56f22ea801271c3f1fa56f6ed63c7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0427
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0864
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2200-0668
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0816
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0424
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-599 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M33-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502761
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N35-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00 |
| filingDate |
2017-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e271bab8420fe2cd2fbb02347d548925
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bec660dc45815934a4d4af90e4e8943
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de6f0cdbeb27751949291acc0a7745bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7b9c731ccaa9164735a8c9b9eb5c4fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7c5846064875e6c995a2c831caf4055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82124e34f9e4d4c44e6d7e0eaab473ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3015223a8a32d4211ec5c45d628e3c44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ca3ad71a69db2593f7ad01e194fdd4d |
| publicationDate |
2019-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3430131-A1 |
| titleOfInvention |
Selection and cloning of t lymphocytes in a microfluidic device |
| abstract |
Methods of expanding T lymphocytes in a microfluidic device are provided. The methods can include introducing one or more T lymphocytes into a microfluidic device; contacting the one or more T lymphocytes with an activating agent; and perfusing culture medium through the microfluidic device for a period of time sufficient to allow the one or more T lymphocytes to undergo at least one round of mitotic cell division. The expansion can be non-specific or antigen-specific. T lymphocytes produced according to the disclosed methods are also provided, along with methods of treating cancer in a subject. The methods of treating cancer can include isolating T lymphocytes from a tissue sample obtained from the subject; expanding the isolated T lymphocytes in a microfluidic device; exporting the expanded T lymphocytes from the microfluidic device; and reintroducing the expanded T lymphocytes into the subject. |
| priorityDate |
2016-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |