| abstract |
The invention provides a method of producing an immune complex preparation based on a secretory immunoglobulin, which is non-human secretion derived, comprising n- providing an industrial scale production system, capable of producing an N-glycosylated Secretory Component, n- producing by such system a Secretory Component comprising at least 0.01 mol non-core fucose per mol Secretory Component, and n- combining said Secretory Component with at least one of IgA or IgM immunoglobulins having a native glycosylation pattern to obtain an immune complex. n The invention provides an isolated recombinant Secretory Component comprising the amino acid sequence of SEQ ID 1, or a functionally active variant thereof, which has a Lewis-type N-glucosylation pattern and at least 2 mol non-core fucose per mol Secretory Component; and nan immune complex preparation based on a secretory immunoglobulin, derived from sources other than human secretions, comprising n- a Secretory Component with a Lewis-type N-glucosylation pattern and at least 0.01 mol non-core fucose per mol Secretory Component, and n- at least one of IgA or IgM immunoglobulins having a native glycosylation pattern. |