Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f8fe90bd741939b669967410a817918 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6817 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-66 |
filingDate |
2017-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89e2340f0d11b41f8edba91c9429bc33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54aa03e88c248fa6097d8697a197abb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14c6ac4717d6508338ef9199a0f399eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ed9ac967d4802e4ade2ed9ae467c70e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cf036e3fec8e73880f0f905956be0c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c28096952639f0c4ede256cd77439cd |
publicationDate |
2018-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-3413920-A1 |
titleOfInvention |
Bioconjugates containing sulfamide linkers for use in treatment |
abstract |
The present invention is based on the surprising finding that the linker employed in a bioconjugate, such as an anti-body-drug conjugate, is not therapeutically inert but has an effect on the therapeutic index of the bioconjugate. The present invention thus concerns a method for increasing the therapeutic index of a bioconjugate and the bioconjugates for use in treatment, in particular cancer. The bioconjugates according to the invention have a sulfamide linker comprising a group according to formula (1). |
priorityDate |
2016-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |