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filingDate 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3395330-A1
titleOfInvention Premixture and pharmaceutical composition for the oral administration of memantine as a permanent suspension or prepared prior to administration to the patient, optionally via an enteral feeding tube, and corresponding methods
abstract Pharmaceutical composition of memantine for administering orally which comprises a premixture comprising: ni) between 74 and 85% w/w total of the premixture of a granulate of pellets comprising memantine between 10 and 15% w/w total of the premixture; coated by first coating of polyvinylpyrrolidone, and a second coating comprising between 80 and 95% w/w total of the coating of cationic copolymer of dimethylaminoethyl methacrylate, butyl methacrylate and methyl methacrylate and between 5 and 20% w/w total of the coating of magnesium stearate; nii) between 4 and 7% w/w total of the premixture of sucralose; niii) between 11 and 19 % w/w total of the premixture of essences. nAll the components have a particle size smaller than 710 microns. The composition can be a suspension, a powder for preparing a suspension or an oral disintegrating tablet. It can also be used to be administered through a nasogastric tube.
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