| abstract |
The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R 1 is -OH, R 2 is -NO 2 and R 3 is H, R 4 and R 5 are H, one of R 6 and R 7 is selected from H, -CONH 2 , and -CONR 9 n 2 , and the other one is selected from -CONR 9 n 2 and -CONR 11 R 9 , wherein R 9 and R 11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off- target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease. |