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publicationDate 2018-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3374497-A1
titleOfInvention Method of modifying macrophage differentiation and immunity
abstract A method of treating a cancer, the method comprising: providing a genetically modified macrophage or monocyte that contains a nucleic acid sequence encoding a Hom-1 polypeptide or a fragment thereof that contains the Hom-1 homeobox domain, wherein the nucleic acid sequence is operably linked to a heterologous promoter and the modified macrophage or monocyte expresses the Hom-1 polypeptide or the fragment thereof; and administering the modified macrophage or monocyte to a subject with a cancer.
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