| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d120bb404b0c17d3bf65f0e5b2c48194 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5256
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10332 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-761
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-761 |
| filingDate |
2014-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_637cd985e3504cff55b6eb10e245caa9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9846d3d16733e4106d3be6893dc07970
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_584e841302b92e1d25dbb9f001c8f06b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdf2cf9914933f3c972fab7bb14385fe |
| publicationDate |
2018-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3372236-A1 |
| titleOfInvention |
Oncolytic adenoviruses armed with heterologous genes |
| abstract |
The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): n5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR wherein: nB1 is bond or comprises: E1A, E1B or E1A-E1B; nBA comprises-E2B-L1-L2-L3-E2A-L4; nB2 is a bond or comprises: E3; nBX is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; nBB comprises L5; nBY is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; nB3 is a bond or comprises: E4; nwherein at least one of BX or BY is not a bond, pharmaceutical compositions comprising the same and use of the viruses and compositions in treatment, particularly in the treatment of cancer. The disclosure also extends to plasmids and processes employed to prepare the said viruses. |
| priorityDate |
2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |