| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d0e1705700a059b200c774b76ce1234 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7042 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7042 |
| filingDate |
2017-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ea3126c8450aa729d8191f15926ad4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3eda824ce50aa60b7c2941b47ffaa36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8302524f79ce1e3a181829432908c57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c35ac6991429055f7a3019961b5e042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04380d4c2c9d66a6493fc80423da1f4b |
| publicationDate |
2018-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3360549-A1 |
| titleOfInvention |
Small molecule therapeutics for treating metachromatic leukodystrophy |
| abstract |
The present invention pertains to a novel treatment of pathologies caused by an increased synthesis or accumulation of sulfolipids such as sulfatide. The invention provides compounds isolated from Epicoccum nigrum strains 749 and 800, which were identified as inhibitors of Sulfotransferase, an enzyme catalyzing the generation of sulfatide. Sulfatides accumulate in the central nervous system (CNS) and lead to a degeneration of white matter. The present invention therefore preferably provides new therapeutic options for treating such diseases by administration of Epicoccum nigrum derived compounds. Further provided are pharmaceutical compositions comprising these compounds. |
| priorityDate |
2017-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |