http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3350335-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1567ae0f1a4843ae7bbef88fa8e1c534 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-90 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-90 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
filingDate | 2016-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7779fd6829fe850b1874c6b5a16e0fc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45616fc0a196fa23d92e6122cf8f4fc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bea909ac7e2f068027c85986de6a1399 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_194b1a8d412eaaa729cd4c34c4992daf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35b5cf83bd2b195e06427e3520bf9fbc |
publicationDate | 2018-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-3350335-A1 |
titleOfInvention | Improved transposon system for gene delivery |
abstract | Described is a transposon system comprising (a) a transposon unit containing inverted terminal repeats (ITRs) or direct terminal repeats (DTRs) that flank a sequence of interest to be inserted into the genome of a target cell; and (b) an RNA encoding a transposase capable of recognizing said ITRs and transposing said sequence of interest into said genome; wherein said RNA encoding said transposase is characterized in that it contains a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidine nucleotides are respectively modified uridine nucleotides and modified cytidine nucleotides. Moreover, described is the use of a said transposon system for the ex vivo gene delivery into a target cell. Further, described is an ex vivo method for gene delivery into a target cell comprising the following steps: (a) bringing into contact the transposon system according to any one of claims 1 to 4 with a cell; (b) culturing said cell under conditions permissive to the culture of said cell. Moreover, described is also a pharmaceutical composition as well as to a kit comprising said transposon system. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11672874-B2 |
priorityDate | 2015-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1905.