| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5cd84f92e5e2ff95dfd19e4e329db3b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-38 |
| filingDate |
2011-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb3604cc7111418d4e96bcd36d0189f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5cb0938379efb264846f5ab973c38db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b6f238b1432e4658d424ad51822e3e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75d48264d197cc5d95837fa4b4d70300
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb3d65a9beda738fe54b27740610267e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2a1f2e5e65d0ce52dab5fcf039439a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e73a51bb4e293571f1e28c9084cf1fd5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_136fb9eb54ab45ded11529a7783973d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ac0e13fc6967ee9356a1a7a90949cc7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bfdcf25eddc9239887319b621b0ab00 |
| publicationDate |
2018-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3345615-A1 |
| titleOfInvention |
Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| abstract |
Monoclonal antibodies to human tissue factor pathway inhibitor (TFPI) are provided. Further provided are the isolated nucleic acid molecules encoding the same. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treatment of genetic and acquired deficiencies or defects in coagulations such as hemophilia A and B are also described. Also described are methods for shortening the bleeding time by administering an anti-TFPI monoclonal antibody to a patient in need thereof. Methods for producing a monoclonal antibody that binds human TFPI according to the present invention are also provided. n In some embodiments, the monoclonal antibodies to TFPI provided have been optimized, for example to have increased affinity or increased functional activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020075083-A1 |
| priorityDate |
2010-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |