| abstract |
The present invention relates to compound of general formula (I) R 1 is selected from H, aryl and alkyl, R 2 is selected from H, alkyl, aryl and CO-R 6 ; R 3 is selected from H, halogen, alkyl, alkenyl, alkynyl, aryl, NHR 7 , NR 7 R 8 , OR 7 and SR 7 ; R 4 is selected from(C 6 -C 12 ) alkyl, (C 2 -C 12 ) alkenyl, (C 2 -C 12 ) alkynyl and (C 6 -C 10 ) aryl, R 5 represents H, R 6 , aryl, OH, OR 6 , O-aryl, SH, SR 6 , S-aryl, CN, NO 2 , CF 3 , COOR 6 , SO 2 NR 6 R 7 , CONR 6 R 7 , NH 2 , NHR 6 , NH-aryl, NR 6 R 7 , NHCOR 6 or aminoacyl; R 6 is alkyl optionally substituted with halogen, OH, SH, NH 2 , O-alkyl, S-alkyl, NH- alkyl or NH-di(alkyl); R 7 and R 8 identical or different are H or alkyl optionally substituted with halogen, OH, SH, NH 2 , O-alkyl, S-alkyl, NH-alkyl or NH-di (alkyl), their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers. |