http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3324956-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8439b9332074bd834f73ff79107938dc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-341 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2016-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cea1b5afd3e4cf9610b98570d0fe0c7 |
| publicationDate | 2018-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3324956-A1 |
| titleOfInvention | Enantiomers of tetrahydro-n,n-dimethyl-2,2-diphenyl-3-furanmethanamine (anavex2-73) and use thereof in the treatment of alzheimer's disease and other disorders modulated by the sigma 1 receptor |
| abstract | The compound (-)-tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride ((-)-ANAVEX2-73, (-)A2-73, (-)AE 37) has been found to exhibit selectivity for sigma-1 (σ1) receptors and stronger agonist activity at the muscarinic M1 acetylcholine receptor than the (+) enantiomer of said compound. Pharmaceutical compositions comprising the (-) enantiomer are disclosed, as are methods of using said (-) enantiomer in the treatment of disorders associated with sigma-1 receptors and the treatment of Alzheimer's disease. Methods of classifying cells with regards to sigma receptor type using the (-) enantiomer are also disclosed. |
| priorityDate | 2015-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.