http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3322702-A1

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filingDate 2016-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0aa4b6d568346b2d947947da33dcc7a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c23ef393c2f31432877ec6d6db3c563
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publicationDate 2018-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3322702-A1
titleOfInvention Cyanopyrrolidines as dub inhibitors for the treatment of cancer
abstract The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase L1 (UCHL1) and ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of cancer and conditions involving mitochondrial dysfunction. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 ,R 2 ,R 3 ,R 4 ,R 5 ,R 6 ,R 7 ,R 8 and R 9 are as defined herein.
priorityDate 2015-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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