http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3312163-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df3db7dfdc978c1cc3f2ba7cc0aee7a4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 |
| filingDate | 2016-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41f3ff52eaa3335b157d5edde2f80878 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a778a27d22678d14f2031afbcc03fa2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd3b37a90bde39c9d3d5d8ce6ba5fc85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_497a34117c0a47bdf9fd9e9b11e9a5e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da607de32b781465991c998f749159d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a941243079b7b6af6d3d48d24ced283e |
| publicationDate | 2018-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3312163-A1 |
| titleOfInvention | Deuterium-substituted dehydrophenylahistin-like compound, preparation method thereof and use in preparation of antitumor drug |
| abstract | Provided are a deuterium-substituted dehydrophenylahistin-like compound, preparation method thereof and use in a preparation of antitumor drugs. The deuterium-substituted dehydrophenylahistin-like compound has a structure of general formula (I), and a synthesis method thereof comprises: firstly conducting a condensation reaction of diacetyldiketopiperazine and an aldehyde intermediate a or a deuterated aldehyde compound b to form a heterocyclic compound c or a deuterium-containing heterocyclic compound d, which is then subjected to a condensation reaction with benzaldehyde and a deuterium-substituted benzaldehyde-like compound to form the deuterium-substituted dehydrophenylahistin-like compound. Also provided are a highly effective deuterated aldehyde intermediate with a high deuterium substitution rate and a deuterium-containing heterocycle intermediate, and a synthesis method thereof. An experiment shows that the deuterium-substituted dehyd- rophenylahistin-like compound provided by the present invention has an effect on tubulin depolymerization and can treat a refractory solid tumor or lymphoma. The present invention provides a method for researching and developing antitumor drugs of the related compound. |
| priorityDate | 2015-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.