| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3de0f1121806c7341dc60c806b9672e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y104-03002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1096
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-245
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y104-01009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y206-01042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0016
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y401-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y401-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-443 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00 |
| filingDate |
2016-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e18f2d47eda0f6f0dafc27d3a45758e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2479dbf5dda47b0f11196914d46bfbaa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d37a930895144b2e71ede9c0d7ce83ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ac62cb78adb3d1fd9faf0ca99f77f98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b7ca7f48234e0b3685bbc5108eee085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54d078334709b20e4f2548abab8e1ea6 |
| publicationDate |
2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3307870-A1 |
| titleOfInvention |
Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid |
| abstract |
The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patient's internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding a branched chain amino acid catabolism enzyme. The disclosure further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders involving the catabolism of branched chain amino acids using the pharmaceutical compositions disclosed herein. |
| priorityDate |
2015-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |