abstract |
The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) TBK l. In particular, the present invention is directed to compounds, which contain on one end an E3 ubiquitin ligase binding moiety which binds to an E3 ubiquitin ligase and on the other end a moiety which binds TBKl such that TBKl is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of TBKl. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of TBKl. |