http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3288962-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e9fa3590248f18bead1bdc777ee06d62 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_612a501f9d512f68c3ecbb7b171b24a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36ecfa211c57cea182c198ca1c4d2455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c75289ceaed857e78afa47ed536872b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_258e917216a0f4402d0f08504c82b3cf |
| publicationDate | 2018-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3288962-A1 |
| titleOfInvention | Novel inhibitors of the enzyme activated factor xii (fxiia) |
| abstract | The present invention relates to a bicyclic inhibitor of the coagulation enzyme activated factor XII (FXIIa) comprising or consisting of the peptide (X 1 )(X 2 )(X 3 ) n (X 4 )(X 5 )(X 6 ) m (X 7 )(X 9 ) l (X 10 )(X 11 )(X 12 )(X 13 )(X 14 ) k (X 15 )(X 16 ), wherein (X 1 ) is present or absent and, if present, is an amino acid; (X 2 ) is an amino acid with a side chain; (X 3 ) is an amino acid and n is between 0 and 3, preferably 0 or 1 and most preferably 0; (X 4 ) is an aliphatic L-amino acid or a cyclic L- amino acid, preferably L, P or an aromatic L-amino acid, and most preferably an aromatic L-amino acid; (X 5 ) is an amino acid; (X 6 ) is an amino acid and m is between 0 and 3, preferably 0 or 1 and most preferably 0; (X 7 ) is an amino acid with a side chain; (X 9 ) is an amino acid and I is between 0 and 3, preferably 0 or 1 and most preferably 0; (X 10 ) is an amino acid; (X 11 ) is an amino acid, preferably Q; (X 12 ) is a hydrophobic L-amino acid, preferably an aliphatic L-amino acid, and is most preferably L; (X 13 ) is an amino acid; (X 14 ) is an amino acid and k is between 0 and 3, preferably 0 or 1 and most preferably 0, (X 15 ) is an amino acid with a side chain; and (X 18 ) is present or absent and, if present, is an amino acid; and wherein the side chains of (X 2 ), (X 7 ) and (X 15 ) are connected via a connecting molecule, said connecting molecule having at least three functional groups, each functional group forming a covalent bond with one of the side chains of (X 2 ), (X 7 ) and (X 15 ). |
| priorityDate | 2015-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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