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filingDate 2016-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71e12a09eaed2a6956b3433ce1d6b54a
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publicationDate 2018-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3287139-A1
titleOfInvention Nerve growth factor composition and powder injection
abstract The present invention discloses a nerve growth factor composition and an injection powder. The nerve growth factor composition consists of a nerve growth factor, a stabilizer, a pH buffer and water, wherein said stabilizer is at least one of sorbitol, dextran, trehalose, raffinose and mannitol. The present invention can avoid the potential risk resulting from the virus or other unknown components carried in albumin by using a carbohydrate or a sugar alcohol instead of albumin as a stabilizer. In addition to the nerve growth factor, only the stabilizer and the pH buffer are contained, without conventional surfactant and supporting agent, and so the present invention has a better safety and a significantly reduced incidence of the adverse reactions; the present invention has definite ingredients, are easily qualitative and quantitative and the stabilizer used therein has a high purity, a wide source and easy long-term mass production, which facilitate the cost control and the product quality improvement; the present invention not only has protective effect on mNGF, but also can ensure the good stability of hNGF and rhNGF in the preparation, transportation and storage processes, and has better clinical medication safety and quality controllability.
priorityDate 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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