| abstract |
The present invention is to provide a novel compound (I-1) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof.n nwherein nA ring is substituted ring of (a), (b) or (c)n nwherein Z is O or NR 19 , nR 19 is hydrogen, C 1-10 alkyl, C 2-8 alkenyl, C 1-10 alkylcarbonyl or C 1-10 alkylsulfonyl, and the other substituents on the A ring form a ring; nR 14 and R X are hydrogen; na broken line represents the presence or absence of a bond, provided that when the broken line represents the presence of a bond, R X is not present; nR 1 is hydrogen or C 1-10 alkyl; nX is C 1-6 alkylene; nR 2 is phenyl or phenyl substituted with at least halogen; nR 3 is hydrogen, halogen, hydroxy, C 1-10 alkyl, C 2-8 alkenyl, C 1-10 alkoxy, C 2-8 alkenyloxy or amino; nor a pharmaceutically acceptable salt, or solvate thereof. |