http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3283624-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1271c5dc0f9289574052f5fa187c0fc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4f8755c361b70eb6af66fd6a114e590 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01074 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6d0979094f50261f19d6f31391ff9a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c450722814bb9a99b8451abf0045f760 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a0182e863331e189b22e43bc931385 |
| publicationDate | 2018-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3283624-A1 |
| titleOfInvention | Mutant human deoxycytidine kinase |
| abstract | The present invention concerns an isolated nucleic acid comprising a sequence encoding a mutant human deoxycytidine kinase (hdCK) capable of converting prodrugs, such as a nucleoside analogue, into cytotoxic drugs. The invention further refers to an isolated vector comprising said nucleic acid of the invention and an isolated host cell genetically engineered with said isolated vector. The invention also refers to a procedure for producing such polypeptides by recombinant techniques. The invention further refers to a pharmaceutical composition comprising an isolated nucleic acid, an expression vector, a host cell, or an isolated mutant hdCK of the invention. Their use as a medicament or their use as a medicament for the treatment of cancer or for the prevention of a viral infection is also part of the invention. The invention further refers to methods for utilizing such polypeptides for the treatment of malignancies and viral infections, methods of sensitizing cells to prodrugs, methods of gene therapy, methods of non-invasive nuclear imaging and methods of inhibiting pathogenic agents in a subject using said mutant hdCK. |
| priorityDate | 2015-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 994.