| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 |
| filingDate |
2016-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_474e0ff1b461c75b391df1a4aa0605a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a1e98609fb07ed774fdf34904522314
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9de613d98e3f72edb1eb23d762270967
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3cf2ecb1484811baed4202aaa971aab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2610af960aabb55ab1391703ba36459
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_583fbe326945eca852ba1628670f5494
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d91758ac40f1523804db8f72bca1f3b |
| publicationDate |
2018-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3280450-A1 |
| titleOfInvention |
Glucose-responsive insulin conjugates |
| abstract |
Insulin conjugates comprising an insulin analog molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A. |
| priorityDate |
2015-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |