http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3267975-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2016-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12d3e24503c6c32be55e51cb8a943fd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca30df65a4a199a1d3574f47e4c0d572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e824e53b48ffb10fad30a6e52801225c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c18cdbd3d823cbdc912a38ba788a92e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a340b4f8ed959b03c5f366e61e5c542 |
| publicationDate | 2018-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3267975-A1 |
| titleOfInvention | Polymer-drug conjugates for combination anticancer therapy |
| abstract | Pharmaceutical compositions comprising two or more therapeutically active agents, such as two or more anticancer agents, conjugated to one or more biocompatible polymers, wherein the molar ratio of the agents and/or schedules of delivery provide a synergistic therapeutic effect, are described. Methods of making and using the pharmaceutical compositions are further described. In one embodiment, the pharmaceutical compositions contain topoisomerase I and topoisomerase II inhibitors conjugated to the same or different biocompatible polymers. The two or more anticancer agents are covalently coupled to the polymer(s), and thereby can be delivered to a tumor at a molar ratio which provides a synergistic effect. Optionally, the agents are coupled indirectly to the polymer(s) via a linker. |
| priorityDate | 2015-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1918.