| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fece74aa8c0cb73d997c194165159cc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J17-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C305-12 |
| filingDate |
2017-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_413dfa5a94a8f2be3f888bd570c9900d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_912a82b1c606fa646c43f3778b4f323f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_591378bee978f0bb787ea96e97641718
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92f663dfb722e915b958e1e34b7fb8b7 |
| publicationDate |
2018-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3263552-A1 |
| titleOfInvention |
Methods for preparing intermediates for the synthesis of obeticholic acid |
| abstract |
The present invention discloses a method for preparing the key intermediates of formula 2 (disilylated derivative) and enones of formula 3 (mixture of E/Z isomers) for synthesis of the active pharmaceutical ingredient - obeticholic acid of formula 1. The principle of the method is that it comprises a reaction of the compound of formula 8 , wherein R 1 is a C1 to C4 linear or branched alkyl, with trimethylsilyl iodide in the presence of a base and a mixture of a polar aprotic and non-polar solvent under an inert atmosphere at a temperature in the range of from 40°C to 70°C. |
| priorityDate |
2016-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |