| abstract |
The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii (T. gondii) calcium dependent protein kinases ( Tg CDPKs) or Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) calcium dependent protein kinases ( Cp CDPKs) using pyrazolopyrimidine and/or imidazo[1,5- α ]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R 1 , and R 3 are defined herein. |