Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
filingDate |
2016-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fd2b6e3518aa4f8cf1ced31004134e5 |
publicationDate |
2017-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-3250037-A2 |
titleOfInvention |
Compositions and methods for creating pancreatic cancer animal model |
abstract |
Certain embodiments are directed kits comprising components for producing a mammalian cancer model. In certain aspects the components are expression vectors. In certain embodiments one or more expression vector is engineered to express a Kras G12D polypeptide, a p53 transcriptional suppressor, SMAD4 transcriptional suppressor, p16/CDKN2 A transcriptional suppressor. In certain aspects the transcriptional suppressor is a short hairpin RNA (shRNA) or other nucleic acid used for RNA interference. |
priorityDate |
2015-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |