http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3246402-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_02cfe54586e1e1cfae14875d0107da56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04 |
| filingDate | 2007-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fc6a936f146280a9003d7a05c6b7c00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efde7885163e93fb9028b5360e50ae5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8c561b3fecc7fd4c397124be4991dd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58cf214dc655bc61abe8d09b2167a7d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c7500b7f31057e5ac613f2d628fb353 |
| publicationDate | 2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3246402-A1 |
| titleOfInvention | Improved mutants of pyrroloquinoline quinone dependent soluble glucose dehydrogenase |
| abstract | The present invention discloses a mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) with improved specificity for glucose as compared to maltose, having a substitution of threonine at position 348 by either glycine, alanine or serine, wherein said mutant additionally comprises, at least one mutation for improving the stability of the mutant and one or more mutation(s) for improving the affinity of the mutant to glucose, and/or one or more mutation(s) for further improving the specificity of the mutant for glucose as compared to maltose, and wherein position 348 correspond to the amino acid positions known from the A. calcoaceticus s-GDH wild-type sequence. Also disclosed are genes encoding such mutant s-GDH, and different applications of these s-GDH mutants, particularly for determining the concentration of glucose in a sample. |
| priorityDate | 2006-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.