| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4b1eeb36c4c7e9225f72a02d76a6c3a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-521 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y600-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2015-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b43ff462f1a7ebab3cc4a166fa33a9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4e38e7b3d397340ade1c8c3a1f0fbc7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5807670f8417344a020080e585505dab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de5a32bb4d22c04fa80a650337aecbc4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_192d3f03720876c2726ca8fe5eab1f42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c5bd0fc9d2f1c79d02245eee6305522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb02cb4aca43280e624368c9308ca159
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d2ca5125de965c540cc9d2ad66810a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72549f8e771bc185cdf218b20711a8a0 |
| publicationDate |
2017-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3231868-A1 |
| titleOfInvention |
O-antigen carbohydrate chain extended salmonella paratyphi a and use thereof |
| abstract |
The present invention discloses a Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cld LT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB4573 3 -OPS Spty 50973 and rEPA4573-OPS Spty 50973 as prepared by using Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020120569-A3 |
| priorityDate |
2014-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |