| abstract |
Structural solid bone replacement body of mineral calcium phosphate cement with remaining hydraulic activity, containing a proportion of hardened calcium phosphate mineral cement and a proportion of non-hardened, hydraulically reactive calcium phosphate cement, characterized in that the bone replacement body of cement strands is constructed with interconnecting pores, that after the construction of a step with hydraulic Hardening and hardening of the strands follows and, on the hydraulically set, hardened surface and in the pores of the replacement body, which is substantially now inert to proteins, human bone sialoprotein is applied by physisorption. As a result, the human bone sialoprotein remains a bioactive non-collagenous bone matrix protein that promotes the differentiation of mesenchymal stem cells into osteoblasts and osteoclasts needed for bone remodeling and remodeling. |