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filingDate 2015-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2017-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3223862-A1
titleOfInvention Metal complex formulations
abstract The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.
priorityDate 2014-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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